SPOT-MAS Multi-Cancer Early Detection Blood Test
SPOT-MAS is a non-invasive, multi-cancer early detection (MCED) test that detects tumor DNA (ctDNA) circulating in the blood. This test incorporates next-generation sequencing (NGS) and AI technologies to analyze the multiple features of ctDNA, enabling early detection for the 10 most common and aggressive cancers(*) from a single tube of blood.
(*) WHO GLOBOCAN South-East Asia Report, 2022
Who should consider SPOT-MAS?
SPOT-MAS is recommended for:
✔️ Adults aged 40 years or older
✔️ Adults aged less than 40 years but have high risks (e.g. who carry genetic mutations, or have unhealthy habits like smoking, drinking alcohol, getting hepatitis B, C.)
✔️ Adults who are seeking to incorporate early cancer detection into their regular health check-ups
SPOT-MAS is not recommended for pregnant women or patients undergoing cancer treatment, or those with the history of bone marrow transplant, blood transfusion within 3 months.
What is SPOT-MAS?
SPOT-MAS test is offered as part of a doctor-supervised medical screening.
SPOT-MAS screens for signals associated with 10 different types of cancers:
- Lung cancer
- Liver cancer
- Breast cancer
- Colorectal cancer
- Stomach cancer
- Esophageal cancer
- Ovarian cancer
- Endometrial cancer
- Nasopharyngeal cancer
- Pancreatic cancer
*The test may not detect all cancer types or all cases of the cancers listed. Clinical judgement is required in interpreting the results.
SPOT-MAS is a laboratory-developed test that uses next-generation sequencing and a multi-feature approach to analyse ctDNA for:
• Methylation patterns
• Fragment length distributions
• Copy number alterations
When abnormal signals are detected, the test also provides a prediction of the likely organ system of origin, which can help guide further clinical evaluation.
This test is conducted in a CAP-accredited laboratory. SPOT-MAS is not a diagnostic test and does not replace diagnostic investigations or standard cancer screening recommendations. Clinical follow-up is required for any abnormal findings.
What to expect?
The SPOT-MAS™ test is conducted under medical supervision to ensure it is appropriate and understood by each patient. Here’s what the process typically involves:
1. Doctor Consultation (Pre-Test)
You will first have a consultation with one of our licensed resident doctors, who will assess your medical history, risk factors, and discuss whether the SPOT-MAS™ test is suitable for you. Any questions or concerns you may have will be addressed during this session.
2. Blood Collection
A standard blood draw will be done in the clinic. Fasting is not required. The process is quick and minimally uncomfortable, similar to routine blood tests.
3. Sample Processing
Your blood sample will be securely processed and sent to MOH-licensed laboratory in Singapore that is CAP-accredited for advanced genomic analysis using ctDNA profiling techniques.
4. Results & Post-Test Review
Results will be ready in approximately 3–4 weeks. Once available, a post-test consultation with the doctor will be arranged to explain the findings, answer questions, and advise on appropriate follow-up if any abnormal signals are detected